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This website is intended for use by patients prescribed HYMPAVZI®▼ (marstacimab) in the UK, and has been developed and funded by Pfizer Ltd.

This information is not intended to be a substitute for advice provided by a healthcare professional. For advice, please consult a healthcare professional.

Adverse event reporting information can be found at the bottom of this page.

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HYMPAVZI: The Pen, Dosage and Administration

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This page summarises HYMPAVZI dosing and administration. Please read the full Patient Information Leaflet and the Instructions for Use that come with the medicine for full details.

Please contact a healthcare professional if you have any further questions.

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The HYMPAVZI prefilled pen

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Before use

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After use

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How much HYMPAVZI to use

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Your treatment will start with an initial loading dose, which will then be followed by a maintenance dose given every week.
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Day 1: loading dose (a higher starting dose to quickly build up levels in the body)

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The recommended initial dose is 300 mg (two ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ 150 mg injections).
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Day 8: start once-weekly maintenance dose

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The recommended maintenance dose is 150 mg once a week.

Depending on how you respond to HYMPAVZI, your doctor may change your maintenance dose as needed, up to a maximum of 300 mg weekly.

You should use HYMPAVZI on the same day each week (any time of the day).

If more than one injection is required to deliver a complete dose, use a different injection site for each.

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Where to Inject HYMPAVZI

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Your healthcare professional will show you and/or your caregiver which areas of the body should be used for the injection. The best place to give HYMPAVZI is the belly area (abdomen) or thigh. Injections to the buttocks should be given by a caregiver or healthcare professional only.

Change the site of injection on your body each time.

If you are using other medicines that must be injected under the skin, these should be given at a different injection site.

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HYMPAVZI Instructions for Use Video

Watch the HYMPAVZI Instructions for Use video, which includes instructions on injection sites, dosage, administration, storage and preparation steps.

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HYMPAVZI Instructions for Use Video
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Getting Started with HYMPAVZI Guide

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Download the Getting started with HYMPAVZI guide to learn about HYMPAVZI, starting HYMPAVZI, instructions for use, preparation steps, injection steps, side effects and important things to know.
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Reporting of Side Effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at https://yellowcard.mhra.gov.uk or search for MHRA Yellow Card in the Google Play or Apple App Store. Any suspected side effects may also be reported to Pfizer medical information on 01304 616161. By reporting side effects, you can help provide more information to the safety of this medicine.